Regression of an ALK-Negative Cerebral Inflammatory Myofibroblastic Tumour by Steroid Therapy: A Case Report and Literature Review

Yijun Ge; Lili Wu; Chengjuan Xie; Qian Da; Ying Dai

Regression of an ALK-Negative Cerebral Inflammatory Myofibroblastic Tumour by Steroid Therapy: A Case Report and Literature Review

Authors

Yijun Ge The Sleeping Disorder Department, Shanghai General Hospital Bengbu Hospital, Bengbu, Anhui, China; Department of Oncology, The First Affiliated of Anhui Medical University, Hefei, Anhui, China
Lili Wu Department of Oncology, The First Affiliated of Anhui Medical University, Hefei, Anhui, China
Chengjuan Xie Department of Neurology, The First Affiliated of Anhui Medical University, Hefei, Anhui, China
Qian Da Department of Pathology, The Affiliated Ruijin Hospital of Shanghai Jiaotong University, Shanghai, China
Ying Dai Department of Oncology, The First Affiliated of Anhui Medical University, Hefei, Anhui, China

Keywords:

Inflammatory myofibroblastic tumours, Central nervous system, Steroid therapy, ALK rearrangement, Cerebral tumours

Abstract

Introduction: Inflammatory myofibroblastic tumours (IMTs) are non-neoplastic lesions characterized by collagenous stroma and polyclonal mononuclear infiltrates. IMTs typically arise in the lung, retroperitoneum or abdominal region but rarely in the central nervous system (CNS). The primary therapeutic option is surgical resection, and other therapies are currently controversial. Case report: We report a case of 23-year-old male ALK-negative cerebral IMT patient from Han population via steroid therapy. No relapse is observed at the follow-up visit. Conclusion: These results support the role of internal medication and promote the use of personalized therapy in genome-profiled IMTs.

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Published

2024-07-04

How to Cite

Ge, Y., Wu, L., Xie, C., Da, Q., & Dai, Y. (2024). Regression of an ALK-Negative Cerebral Inflammatory Myofibroblastic Tumour by Steroid Therapy: A Case Report and Literature Review. Journal of Cancer Biomoleculars and Therapeutics, 1(1), 11–15. Retrieved from https://eternopublisher.com/index.php/jcbt/article/view/5